Tumors-on-Chips: Debugging the Cancer Research Model

All models are wrong — but some models are less wrong than others. At the interface of tissue engineering and microfluidic technology, tumor-on-chip systems offer tantalizing possibilities of unraveling human tumor biology and drug responses, while minimizing the time, cost, and ethical concerns of animal research.

How Artificial Intelligence is Transforming Cancer Immunotherapy

Immunotherapy has enormous potential to provide cancer patients with a treatment which is more personalised, more precise, and more effective than current therapies, but evidently its promises will only come to fruition with the assistance of improved predictive algorithms and bioinformatics tools. Recent explosions in publicly available cancer genomic data, coupled with advancements in machine learning methods is ensuring that the marriage of computation and biology will help to address challenges facing immunotherapy in the coming decade. Here we will take a look at how scientists are starting to implement artificial intelligence methods to predict neoepitopes for cancer vaccine development.

Neu5GC – Alien Meat Sugars in Human Cancer

The epidemiological link between red meat and cancer is no longer debatable – what remains uncertain is how exactly this happens, and why the human species appears to be unique in its susceptibility.

Lab Rats Lost in Translation: Why We Use Animals in Research, and Why We Really Shouldn’t

This is a story of mice and men. It is not a happy story – not for us, and not for them. It is estimated that about 115 million animals are used annually in biomedical research and drug testing around the world. Is this justified? Many of the diseases which are studied using animal models do not even naturally occur in animals. Owing to inherent genetic differences, the ability of animal models to predict human drug responses is tenuous at best.
Why is it that we recoil with visceral disgust when we see a man kicking a dog in the street, but not when we see a man in a clean white coat injecting a toxic substance into a mouse, or even a beagle, in a clean white laboratory? Is humanity suffering from a case of moral schizophrenia?